Sheep are susceptible to infectious enterotoxemia, other animals (cattle, goats, horses, pigs, camels, wild animals) also get sick.
Of the laboratory animals, guinea pigs, white mice and young cats are the most susceptible, while rabbits and rats are less susceptible.
Enterotoxemia affects 1-6 month old lambs on pasture. Sheep of 10-12 months of age also get sick with it.

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Sources of the causative agent of infection are sick animals and microcarrier sheep. Transmission factors can be all environmental objects contaminated by this pathogen. The occurrence of the disease is facilitated by various conditions that disrupt the motor and secretory functions of the gastrointestinal tract of animals. Most often this is noted with a sharp change in the quality of Ivermectin.

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The disease appears more often in spring, less often in autumn, in some cases it also occurs in winter, especially with abundant feeding of animals with grain, concentrated feed. Many authors associate the emergence and spread of enterotoxemia in sheep with the natural-climatic and soil-meteorological conditions of the area. In rainy years, the disease is more common and can become widespread.

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There are several types of anaerobic enterotoxemia: hemorrhagic enterotoxemia occurs more often in adult sheep; ends with sudden death; infectious enterotoxemia, accompanied by softening of the kidneys, is observed in sheep of Ivermectin. In the first case, the disease occurs suddenly and the animals quickly die. The main toxic factor of this microbe is epsilon toxin.

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The causative agent of the disease is an anaerobic microbe from the family Bacillaceae, genus Clostridium Cl. perfringens types D and C, less often A. Forms spores. Course and symptoms. The disease in sheep proceeds super-acutely, acutely and chronically. The incubation period depends on the degree of intoxication and the resistance of stromectol pills. With artificial infection, it is 2-6 hours; according to our observations - from 60 minutes to 12 hours.

In the hyperacute course of the disease, animals die suddenly (within 2-3 hours), clinical signs usually do not appear. This form of the disease is observed mainly in young and well-fed sheep. Dead animals are more often found in the sheepfold or pasture in the morning. Sick sheep stop grazing, they are oppressed, they fall behind the flock. Body temperature is normal or slightly elevated, the pulse is weak, rapid. Impaired coordination of movementsthe animal stumbles, sometimes moves on carpal joints, falls, makes swimming movements with its limbs, serous or serous-hemorrhagic mucus is released from the mouth and nose, salivation is observed.

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There is bloody diarrhea.
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Increased urination.
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Clonic and tonic convulsions are noted, the animal gnashes its teeth, the eyes are dilated.
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The mucous membranes are hyperemic.

In the acute course of the disease, body temperature rises to 41 ° C, depression, loss and perversion of appetite, diarrhea with streaks of blood and mucus are noted. The gait is shaky, paresis of the limbs develops. The animal stands still for a long time, indifferent to the environment. There are signs of damage to the nervous system. When moving forward, the animal makes jerky movements, falls, rises and falls again, rows its limbs or lies in a coma. Convulsive muscle contractions are observed, the head is thrown back. Death occurs in 2-3 days, sometimes in 5-7 days.

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The subacute course of the disease occurs in adult sheep and lambs, sometimes it is a continuation of a hyperacute or acute course.

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